Dominantly transmitted focal dystonia in families of patients with musician's cramp.
نویسندگان
چکیده
Musician's dystonia is generally considered a sporadic disorder. We present three families with the index patient affected by musician's dystonia, but other forms of upper limb focal task-specific dystonia (FTSD), mainly writer's cramp, in seven relatives. Our results suggest a genetic contribution to FTSD with phenotypic variability, including musician's dystonia.
منابع مشابه
Sensorimotor reorganization by proprioceptive training in musician's dystonia and writer's cramp.
OBJECTIVE The sensorimotor organization (SMO) of the motor hand area is abnormal in focal hand dystonia and likely contributes to symptom manifestation. In healthy subjects SMO is changed by training with proprioceptive stimulation. Here we test whether similar interventions reverse the abnormal SMO in musician's dystonia and writer's cramp. If so, they could be developed for therapeutic applic...
متن کاملFocal dystonia in musicians: From phenomenology to therapy
INTRODUCTION Focal dystonia in musicians, also known as musician's cramp, is a task-specific movement disorder which presents itself as a painless muscular incoordina-ABSTRACT Background: Musician's dystonia is a task-spe
متن کاملPii: S1388-2457(00)00460-0
Objective: The in ̄uence of muscle vibration (MV) as a strong proprioceptive input on motorcortical excitability was studied in 5 patients with musician's cramp, 5 musician controls and 5 non-musician controls. Methods: The relaxed ̄exor carpi radialis (FCR), involved in the dystonic movement in all patients, was vibrated using low frequency (80 Hz) and low amplitude (0.5 mm). Transcranial magne...
متن کاملDisturbances of grip force behaviour in focal hand dystonia: evidence for a generalised impairment of sensory-motor integration?
BACKGROUND Focal task specific dystonia occurs preferentially during performance of a specific task. There may be an inefficiently high grip force when doing manipulative tasks other than the trigger task, possibly reflecting a generalised impairment of sensory-motor integration. OBJECTIVE To examine how well subjects with writer's cramp (n = 4) or musician's cramp (n = 5) adapted their grip ...
متن کاملThe challenge of diagnosing focal hand dystonia in musicians.
BACKGROUND AND PURPOSE To most clinicians, medical problems in musicians, particularly those concerning focal hand dystonia, constitute an unfamiliar domain difficult to manage. The latter can importantly influence diagnostics and the course of treatment. The purpose of this study was to enlighten the issue and to identify possible problems in diagnosing musicians' cramp within the Spanish medi...
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ورودعنوان ژورنال:
- Neurology
دوره 67 4 شماره
صفحات -
تاریخ انتشار 2006